Pharmacokinetics of acetaminophen, codeine, and the codeine metabolites morphine and codeine-6-glucuronide in healthy Greyhound dogs

Presence and formation of codeine and morphine in the rat.

Endogenous codeine and morphine were identified in rat brain by immunological determination following HPLC. To demonstrate occurrence of a biosynthetic pathway to morphine in mammals similar to that used by the poppy plant, (+)-salutaridine, (-)-thebaine, and (-)-codeine were administered to rats intravenously. These compounds, which are intermediates in the synthesis of morphine in Papaver som...

Codeine intoxication in the neonate.

Although opiates can provide patients with relief from pain and the discomfort of cough, the routine prescription of these drugs for infants demands caution and concern. Infants, particularly neonates, are not merely small adults requiring smaller dosages, but rather uniquely different patients. Neonates present with an immature physiology and biochemistry with respect to drug metabolism. We re...

Codeine and methadone interactions

Cytochrome P450; Drug Interactions; CYP3A4; CYP2D6; Metabolites; Opioids. Introduction metabolism of codeine, fentanyl, methadone, oxycodone, and . WebMD provides information about interactions between Codeine Sulfate Oral and. Buprenorphine effects in methadone-maintained volunteers: effects at two . Methadone is a potent drug, and can interact with other drugs to have block the high of other ...

Morphine and Codeine in Biological Fluids: Approaches to Source Differentiation.

Heroin, morphine, and codeine are among the most abused opiate analgesics today. Analysis of individuals' urines for morphine and codeine is sued as an indication of prior ingestion of these dugs. Poppy seeds and products containing poppy seeds are found to have small amounts of morphine and codeine (usually less than 200 µg morphine/g seeds and much less codeine), which is enough to produce a ...

Interaction of morphine- and codeine-epoxides with opiate receptor.